Epithelial Progenitor Differentiation
Gene co-expression module in Tuft cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
CCND2 (cyclin D2, G1/S transition), KRT19 (epithelial keratin), TAGLN2 (cytoskeletal), CEACAM5 (epithelial adhesion/differentiation marker), ANXA2 (membrane scaffold), FERMT1 (integrin activation), MRPS12/MRPL3/MRTO4 (mitochondrial ribosomal subunits), PA2G4 (ribosome biogenesis), NANS (sialic acid biosynthesis) collectively indicate an early epithelial differentiation state with active ribosome biogenesis and cytoskeletal remodeling. The pre_tuft enrichment and CCND2 suggest a G1-phase progenitor transitioning toward epithelial identity.
Genes
Most correlated modules
- Metallothionein Stress Response · correlation 0.99
- Precursor Cell Cycle · correlation 0.99
- Ribosome Biogenesis · correlation 0.99
- Secretory Progenitor Commitment · correlation 0.98
- Progenitor S-phase · correlation 0.98
- G2/M Progenitor Proliferation · correlation 0.97
- Mitotic Spindle Assembly · correlation 0.97
- Pre-tuft WNT Secretion · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.