Metallothionein Stress Response
Gene co-expression module in Tuft cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
MT1F and MT1M (metallothioneins 1F and 1M, heavy metal/oxidative stress response), FABP5 (fatty acid binding protein 5, lipid handling and stress), MGST1 (microsomal glutathione S-transferase 1, detoxification), AGR3 (anterior gradient 3, ER chaperone related to AGR2), DNPH1 (nucleotide pool sanitization), NME1 (nucleoside diphosphate kinase, proliferation/metastasis suppressor), PXMP2 (peroxisomal membrane protein). The metallothionein dominance combined with MGST1 and FABP5 indicates a metal/oxidative stress detoxification program in pre-tuft progenitors, likely reflecting the redox-active intestinal environment.
Genes
Most correlated modules
- Precursor Cell Cycle · correlation 0.99
- Secretory Progenitor Commitment · correlation 0.99
- Epithelial Progenitor Differentiation · correlation 0.99
- Progenitor S-phase · correlation 0.99
- Prostaglandin Biosynthesis · correlation 0.98
- Ribosome Biogenesis · correlation 0.98
- Mitotic Spindle Assembly · correlation 0.97
- Progenitor Cell Proliferation · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.