Pre-tuft Biosynthetic
Gene co-expression module in Tuft cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
All genes are strongly enriched in pre_tuft cells. Hub genes include DHFR (folate/nucleotide biosynthesis), GFPT1 (hexosamine biosynthesis), ACSL5 (fatty acid-CoA ligation), MPC1 (mitochondrial pyruvate import), MRPL32 (mitochondrial translation), ACTL6A (BAF chromatin remodeling), and MAP2K6 (stress MAPK). Together these reflect a biosynthetic and metabolic program supporting pre-tuft progenitor state, with folate metabolism, lipid activation, and mitochondrial function as key themes.
Genes
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.98
- Prostaglandin Biosynthesis · correlation 0.98
- Glycolytic TCA Metabolism · correlation 0.98
- Progenitor S-phase · correlation 0.97
- Secretory Progenitor Commitment · correlation 0.97
- Pre-tuft WNT Secretion · correlation 0.96
- ATP Synthase OxPhos · correlation 0.96
- Progenitor Metabolic Reprogramming · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.