RNA Splicing Translation
Gene co-expression module in Tuft cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
LSM7 and TXNL4A are both spliceosomal Sm/Sm-like proteins involved in pre-mRNA splicing. EIF3D is a core subunit of the eIF3 translation initiation complex. MRPL21 and MRPL57 are mitochondrial large ribosomal subunit proteins. NDUFB6 is a Complex I accessory subunit. S100A14 and TMEM54 are epithelial identity markers enriched in pre_tuft. TRAPPC6A (vesicle trafficking), MISP (mitotic spindle positioning), NUDT1 (oxidized nucleotide sanitization) are peripheral. The module represents a mixed pre_tuft housekeeping program with RNA splicing and translation as the most coherent sub-theme, in the context of the broader pre_tuft progenitor biosynthetic neighborhood.
Genes
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.97
- ER Membrane Biogenesis · correlation 0.97
- Mitochondrial Translation · correlation 0.96
- Pre-tuft Biosynthetic · correlation 0.96
- ATP Synthase OxPhos · correlation 0.96
- Protein Folding Proteostasis · correlation 0.96
- Mitochondrial OxPhos Assembly · correlation 0.95
- Pre-tuft Differentiation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.