ABHD11 — Abhydrolase domain containing 11
ABHD11 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABHD11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | GPCR Peptide Signaling Secretion | AKIRIN1, AVPI1, BAG1, DNAJA1, DNAJA2, EDN1, FBXO33, G3BP2 +31 more | View in SCUBA |
About the gene
| Synonyms | PP1226, WBSCR21 |
|---|---|
| Chromosome | 7: 73736094-73738852 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol. 1,2- diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn- glycerols (By similarity). The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts. In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.