GPCR Peptide Signaling
Gene co-expression module in Colonocytes
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 40 genes have a known function matching the annotation |
Why this annotation
EDN1 (endothelin-1) is a secreted vasoactive peptide that also acts as an autocrine/paracrine signaling molecule in epithelial cells. GNAI3 mediates inhibitory GPCR signaling downstream of EDN1 and other receptors. TRAF4 links receptor signaling to downstream kinase cascades. WEE1 and PPP2CA regulate cell cycle checkpoints. DNAJA1 and BAG1 are chaperone co-factors involved in proteostasis and stress responses. VMP1 and NRBF2 participate in autophagy. G3BP2 is a stress granule component. The module is strong in coherence but functionally mixed, with a core of GPCR/peptide signaling (EDN1, GNAI3) combined with proteostasis/stress elements. Positive treatment response in CD suggests recovery of normal epithelial signaling.
Genes
Most correlated modules
- Chromatin Transcriptional Control · correlation 0.89
- RNA-binding & Splicing · correlation 0.84
- Actin Cytoskeletal Regulation · correlation 0.77
- Focal Adhesion Migration · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.