FBXO33 — F-box protein 33
FBXO33 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBXO33's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Late Activation Autophagy Immune regulation | BCL3, BRD1, CREM, DUSP8, FAM177A1, FOSL2, GABARAPL1, IRF2BP2 +19 more | |
| Mucosal-associated invariant T cell | Post-translational Regulation Housekeeping | CCDC93, CD55, GALC, KCTD20, KDM2B, MGAT4A, MSL2, PDE4D +8 more | |
| Neutrophils | Ubiquitin-Proteasome Turnover Housekeeping | BLTP3B, CACUL1, CLIP1, FBXL20, FGD3, IL18RAP, KIF13A, LMTK2 +10 more |
About the gene
| Synonyms | Fbx33 |
|---|---|
| Chromosome | 14: 39397684-39432466 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.