G3BP2 — G3BP stress granule assembly factor 2
G3BP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
G3BP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Signaling Regulation BCR/AP1/NFKb pathway | CBLB, CYTIP, FCRL2, FCRL3, HIVEP1, ITPR2, IVNS1ABP, MOB3A +5 more | View in SCUBA |
| CD4⁺ T cells | Chemokine Migration migration & adhesion | CCR6, CYTIP, DDX24, FRMD4B, GNG2, GPBP1, KMT2E, PDE4B +7 more | View in SCUBA |
| Gamma-delta T cells | ER Stress Response Stress | ATP1B3, ATP2A2, BACH1, CPD, EIF2AK3, FAM118A, GRK5, HBP1 +13 more | |
| Innate lymphoid cells | NR4A Activation Response activation | ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Stress Granule Response Stress | BZW1, CRTC2, EZR, HERPUD2, HNRNPUL1, MAP3K8, MAPK1IP1L, RNF138 +3 more | |
| Natural Killer cells | NK Immune Checkpoint Immune regulation | AKAP13, CHD1, LIMS1, MORF4L2, P2RY10, PTPN22, RANBP2, SAMSN1 +1 more | View in SCUBA |
About the gene
| Synonyms | KIAA0660 |
|---|---|
| Chromosome | 4: 75641849-75724589 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Host-virus interaction, Immunity, Innate immunity, mRNA transport, Transport |
Function
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.