BAG1 — BAG cochaperone 1
BAG1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BAG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcriptional Repressor Complex DNA/chromatin regulation | CAB39, CLEC2B, EBP, FBXO31, GFI1, MAN1A1, MAP2K1, MFSD6 +14 more | |
| Goblet cells | Epithelial Maturation Epithelial development | AMN, CDC42EP5, CST3, KRT10, NTRK2, NXPE4, PHGR1, PPDPF +2 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, C1orf35, CHCHD1, CHMP5, DNAJC7, EIF2S2 +37 more | View in SCUBA |
| Lymphatic endothelial | RNA Protein Homeostasis RNA processing & translation | ADRM1, COPRS, ILF2, RAB32, RAN, RBM8A, SLC25A5, SNRPB +2 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1, DYNLRB1 +20 more | View in SCUBA |
| Smooth muscle cells | Post-translational regulators Housekeeping | ANXA11, BANF1, CALM3, CAMTA1, ERH, HMGN3, MYO1C, NENF +6 more | View in SCUBA |
About the gene
| Chromosome | 9: 33247820-33264720 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Apoptosis |
Function
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.