DNAJA1 — DnaJ heat shock protein family (Hsp40) member A1

DNAJA1 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DNAJA1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Early Response Stress Stress	ANKRD37, GTF2B, NR4A2, SAT1, SIK1, SOCS3, UBB, UBC	View in SCUBA
CD4⁺ T cells	Heat Shock Response Stress	ANKRD37, CHORDC1, DEDD2, DNAJA4, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1 +12 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT3, HSP90AA1, HSP90AB1, HSPA8, HSPD1 +4 more	View in SCUBA
Endothelial	Heat Shock Response Stress	BAG3, DNAJA4, HSPA8, HSPD1, HSPE1, HSPH1, IER5, MRPL18 +2 more	View in SCUBA
Fibroblasts	NF-κB Immediate Early Inflammatory	ATF3, DUSP1, HLA-E, HSPA8, IRF1, MAFF, NFKBIA, NFKBIZ +4 more	View in SCUBA
Gamma-delta T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT4, CHORDC1, DNAJB1, DNAJB4, HSP90AA1 +13 more
Glial cells	Integrated Stress Response Stress	ATF3, CCNL1, DUSP1, HSPA8, HSPH1, KLF4, MAFF, NR4A1 +2 more	View in SCUBA
Goblet cells	Heat Shock Response Stress	EIF1AX, EIF5, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPB1 +5 more	View in SCUBA
Innate lymphoid cells	Immediate Early Response activation	ATF3, BRD2, BTG2, CCNL1, DDX3X, EGR1, EIF4A3, EIF5 +8 more	View in SCUBA
Lymphatic endothelial	Integrated Stress Response Stress	ATF3, CSRNP1, DDIT3, EIF4A2, HSP90AB1, PPP1R15A, RSRC2, SERTAD1 +2 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA4, DNAJB1, DNAJB4, DUSP1 +39 more	View in SCUBA
Monocytes	Heat Shock Response Stress	CHORDC1, DNAJB1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPD1 +4 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, FOSB +7 more
Neutrophils	Heat Shock Response Stress	ATP6V0C, CYB5D1, DUSP2, GNG10, HMOX1, HSP90AA1, HSP90AB1, HSPA1A +4 more
Smooth muscle cells	Heat Shock Response Stress	C12orf65, CEMIP2, CHORDC1, DNAJB1, FOSB, H2AFX, HSP90AA1, HSPA1A +8 more	View in SCUBA

About the gene

Synonyms	dj-2, hdj-2, HSJ2, HSPF4, NEDD7
Chromosome	9: 33025273-33039907
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Molecular function	Chaperone

Function

Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co- chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.