EDN1 — Endothelin 1
EDN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EDN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Notch Secretory Specification Epithelial development | EREG, FKBP1A, GPRC5C, HES4, HES5, MYC, NOTCH2, PDGFA +4 more | View in SCUBA |
| Pericytes | Pericyte Identity Developmental | AIF1L, ALPL, ARL15, ASRGL1, FAM89A, GFOD1, LPCAT2, OCIAD2 +1 more | View in SCUBA |
About the gene
| Synonyms | ET1 |
|---|---|
| Chromosome | 6: 12290361-12297194 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Vasoactive, Vasoconstrictor |
Function
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.