ADAM12 — ADAM metallopeptidase domain 12
ADAM12 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAM12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | PD-L1 checkpoint Immune regulation | CASS4, CCDC88B, CD274, GALNT10, HUWE1, INPP5D, KIF3B, LASP1 +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-β Immune Regulation Immune regulation | AFF1, AKAP9, FNBP4, IKZF3, INPP4A, MAN1A1, NSD3, PCNX1 +8 more |
About the gene
| Synonyms | MCMPMltna, MLTN |
|---|---|
| Chromosome | 10: 126012381-126388477 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | Cell adhesion |
Function
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.