IKZF3 — IKAROS family zinc finger 3
IKZF3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IKZF3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators BCR/AP1/NFKb pathway | AKNA, ATF7IP, DNAJB14, FCHSD2, GOLGA4, INPP5D, MYCBP2, PDE7A +3 more | View in SCUBA |
| CD4⁺ T cells | MAF regulatory program Immune regulation | AKAP13, ARID4B, DTHD1, FYN, ISCU, LIMA1, LIMS1, MAF +12 more | View in SCUBA |
| CD8⁺ T cells | CD8 Effector Maturation T cell maturation | AKAP13, ATXN1, CD81, DDX17, DDX3X, ETS1, JUND, MXD4 +8 more | View in SCUBA |
| Gamma-delta T cells | T Cell Calcium-Cytoskeletal T cell maturation | CASP8, CRACR2A, GCNT1, IQGAP1, MAP4, PRKAR1A, PSEN1, RFFL +5 more | |
| Mucosal-associated invariant T cell | TGF-β Immune Regulation Immune regulation | ADAM12, AFF1, AKAP9, FNBP4, INPP4A, MAN1A1, NSD3, PCNX1 +8 more | |
| Natural Killer cells | Mature NK Identity Differentiation | ABCB1, ADAM28, ADGRG3, CCDC141, CD160, CMTM7, DZIP3, LZTFL1 +5 more | View in SCUBA |
About the gene
| Synonyms | Aiolos, ZNFN1A3 |
|---|---|
| Chromosome | 17: 39757718-39864312 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | B-cell activation, Transcription, Transcription regulation |
Function
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.