TGF-β Immune Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
TGFBR2 is the top hub (core membership) and encodes a key TGF-β receptor central to immune tolerance and T cell regulation. IKZF3 (Aiolos) is a lymphocyte-specific Ikaros family transcription factor induced by TGF-β signaling in T cells. INPP4A negatively regulates PI3K/Akt, consistent with TGF-β-mediated suppression of T cell activation. SLAMF6 is a lymphocyte-specific surface receptor. RAPGEF6 modulates integrin outside-in signaling. NSD3 and AFF1 are chromatin/transcriptional co-regulators. Together, this module reflects TGF-β-driven immune regulatory programming in MAIT cells, consistent with tolerance or tissue-resident quiescence.
Genes
ADAM12, AFF1, AKAP9, FNBP4, IKZF3, INPP4A, MAN1A1, NSD3, PCNX1, RAPGEF6, SLAMF6, SRSF11, STT3B, STX16, TGFBR2, UBE2H, ZBTB38
Most correlated modules
- Epigenetic Maintenance · correlation 0.93
- Chromatin Epigenetic Regulation · correlation 0.91
- Lymphocyte Survival · correlation 0.87
- Histone Modification · correlation 0.87
- RNA Splicing Processing · correlation 0.87
- Chromatin Remodeling · correlation 0.83
- Apoptosis Regulation · correlation 0.82
- Vesicle Membrane Trafficking · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.