INPP4A — Inositol polyphosphate-4-phosphatase type I A
INPP4A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
INPP4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicular trafficking Housekeeping | ACSL4, ARL8B, BLOC1S2, C3orf38, DTX3L, EFCAB14, GGA2, HMGXB3 +17 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ABHD12, ACAP2, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP +18 more | |
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ABHD15, ALDOC, ARL2BP, C20orf204, CCL20, CPNE7, EIPR1, ERG28 +21 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-β Immune Regulation Immune regulation | ADAM12, AFF1, AKAP9, FNBP4, IKZF3, MAN1A1, NSD3, PCNX1 +8 more |
About the gene
| Synonyms | INPP4 |
|---|---|
| Chromosome | 2: 98444854-98594392 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid metabolism |
Function
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D- aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.