MAN1A1 — Mannosidase alpha class 1A member 1

MAN1A1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MAN1A1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	TCR Complex Activation TCR/AP1/NFKb pathway	ABHD17A, ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81 +14 more	View in SCUBA
Enterocytes	Brush-border enterocyte Absorption	CD2AP, CEACAM20, ERBIN, GK, HHLA2, MAPK6, NCKAP5, SLC36A1	View in SCUBA
Gamma-delta T cells	Transcriptional Repressor Complex DNA/chromatin regulation	BAG1, CAB39, CLEC2B, EBP, FBXO31, GFI1, MAP2K1, MFSD6 +14 more
Innate lymphoid cells	IFN-gamma Response Inflammation	APOL6, B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A +16 more	View in SCUBA
Macrophages	Macrophage Migration Migration & adhesion	CEMIP2, CPM, EPB41L2, EPS8, GBE1, ITGA9, KCNQ1, MEF2C +12 more	View in SCUBA
Mucosal-associated invariant T cell	TGF-β Immune Regulation Immune regulation	ADAM12, AFF1, AKAP9, FNBP4, IKZF3, INPP4A, NSD3, PCNX1 +8 more

About the gene

Chromosome	6: 119177205-119349761
Predicted location	Membrane
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins
Molecular function	Glycosidase, Hydrolase

Function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.