ADAMTS12 — ADAM metallopeptidase with thrombospondin type 1 motif 12
ADAMTS12 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAMTS12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Fibrotic ECM Remodeling ECM remodeling | ADAMTS2, CD248, COL12A1, COL5A2, FSTL1, LOXL2, NID2, PAMR1 +2 more | View in SCUBA |
About the gene
| Chromosome | 5: 33523535-33892019 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Metalloprotease that may play a role in the degradation of COMP. Also cleaves alpha-2 macroglobulin and aggregan. Has anti- tumorigenic properties.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.