NID2 — Nidogen 2
NID2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NID2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1 +15 more | View in SCUBA |
| Fibroblasts | Inflammatory ECM Remodeling ECM remodeling | ABRACL, ADAMTS2, CD82, CHI3L1, COTL1, GGCT, LXN, MT2A +5 more | View in SCUBA |
| Pericytes | Fibrotic ECM Remodeling ECM remodeling | ADAMTS12, ADAMTS2, CD248, COL12A1, COL5A2, FSTL1, LOXL2, PAMR1 +2 more | View in SCUBA |
About the gene
| Chromosome | 14: 52004809-52069059 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell- extracellular matrix interactions
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.