Fibrotic ECM Remodeling
Gene co-expression module in Pericytes
| Category | ECM remodeling |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include ADAMTS2 (procollagen N-proteinase), ADAMTS12 (ECM protease), COL5A2, NID2, LOXL2 (lysyl oxidase-like 2, collagen/elastin crosslinker critical in fibrosis), SPON2, CD248/endosialin (pericyte/stromal fibroblast marker), TNS3 (tensin, focal adhesion/ECM), COL12A1 (FACIT collagen), FSTL1 (follistatin-like, TGF-β modulator), PAMR1. This module has the highest inflammation delta in the batch (UC=1.319, CD=1.262) and strong remission reversal. LOXL2+ADAMTS2+ADAMTS12+COL5A2+COL12A1+FSTL1 constitute a fibrotic ECM remodeling program. CD248 confirms pericyte/stromal identity.
Genes
ADAMTS12, ADAMTS2, CD248, COL12A1, COL5A2, FSTL1, LOXL2, NID2, PAMR1, SPON2, TNS3
Most correlated modules
- BM Collagen Production · correlation 0.94
- Fibrillar Collagen Production · correlation 0.93
- Basement Membrane Remodeling · correlation 0.92
- Basement Membrane Assembly · correlation 0.90
- Pericyte Inflammatory Activation · correlation 0.89
- Fibrotic ECM Remodeling · correlation 0.89
- ER Protein Folding · correlation 0.82
- Complement Regulatory Pericyte · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.