COL5A2 — Collagen type V alpha 2 chain
COL5A2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL5A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Complement Innate Immune Inflammation | C1R, C1S, CD47, CNDP2, CTSS, GRINA, GSDMD, LGALS9 +9 more | View in SCUBA |
| Fibroblasts | Collagen ECM Production ECM production | AEBP1, ANGPTL2, ANTXR1, CERCAM, CLTC, COL1A1, COL1A2, COL3A1 +12 more | View in SCUBA |
| Glial cells | Collagen ECM Deposition ECM remodeling | COL15A1, COL18A1, COL1A1, COL28A1, COL4A1, COL4A2, COL6A2, FLNA +2 more | View in SCUBA |
| Pericytes | Fibrotic ECM Remodeling ECM remodeling | ADAMTS12, ADAMTS2, CD248, COL12A1, FSTL1, LOXL2, NID2, PAMR1 +2 more | View in SCUBA |
| Smooth muscle cells | Collagen-Laminin Deposition ECM remodeling | COL5A1, COL6A3, LAMA4, LAMB1, NEGR1, PARVA, PCDH7, RAB32 +4 more | View in SCUBA |
About the gene
| Chromosome | 2: 189031898-189225312 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.