ADAMTS2 — ADAM metallopeptidase with thrombospondin type 1 motif 2
ADAMTS2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAMTS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory ECM Remodeling ECM remodeling | ABRACL, CD82, CHI3L1, COTL1, GGCT, LXN, MT2A, NID2 +5 more | View in SCUBA |
| Pericytes | Fibrotic ECM Remodeling ECM remodeling | ADAMTS12, CD248, COL12A1, COL5A2, FSTL1, LOXL2, NID2, PAMR1 +2 more | View in SCUBA |
About the gene
| Synonyms | ADAM-TS2, ADAMTS-3, hPCPNI, NPI, PCINP |
|---|---|
| Chromosome | 5: 179110853-179345461 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | Collagen degradation |
Function
Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.