CD6 — CD6 molecule
CD6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 effector Th17 fate | CLSTN3, CTDSP1, IL17A, ITPRIPL2, MAP3K4, MPRIP, NFIL3, NMRK1 +6 more | View in SCUBA |
| Gamma-delta T cells | Naive T cell quiescence T cell maturation | ADAP1, ARL4C, BCL9L, BMAL1, CALM1, CAMK1D, CD44, CD5 +10 more | |
| Mucosal-associated invariant T cell | mRNA 3' Processing RNA processing & translation | ATXN2L, DNM2, EIF4A2, HNRNPDL, MLLT6, NOP58, RBM15B, RNF10 +3 more |
About the gene
| Synonyms | Tp120 |
|---|---|
| Chromosome | 11: 60971680-61020377 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins, Predicted secreted proteins |
| Biological process | Adaptive immunity, Cell adhesion, Immunity, Innate immunity |
Function
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium- dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.