Naive T cell quiescence
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes KLF2 and KLF3 are canonical markers of naive/quiescent lymphocytes. P2RY8 marks naive B and T cells. CD5, CD6 are mature T cell surface markers enriched on naive cells. ORAI1, CALM1, CAMK1D reflect tonic calcium signaling. RORA and BMAL1 indicate circadian metabolic regulation. TGFB1 and ADAP1 support a regulatory/quiescent T cell identity. BCL9L participates in Wnt/homeostatic programs. Together this defines a naive quiescent gd T cell state driven by KLF2.
Genes
ADAP1, ARL4C, BCL9L, BMAL1, CALM1, CAMK1D, CD44, CD5, CD6, DDX47, DNLZ, EPHA4, KLF2, KLF3, ORAI1, P2RY8, RORA, SPOCK2, TGFB1
Most correlated modules
- Cytotoxic Effector Program · correlation 0.85
- TCR-Cytokine Signaling · correlation 0.83
- Immune Synapse Cytoskeleton · correlation 0.82
- TGF-β Migration Program · correlation 0.80
- Coinhibitory Checkpoint · correlation 0.80
- T Cell Development · correlation 0.78
- TCR Proximal Signaling · correlation 0.77
- Effector IFN Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.