ADGRG3 — Adhesion G protein-coupled receptor G3
ADGRG3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADGRG3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | BPI Antibacterial Response Antibacterial | ANXA3, BPI, CMTM2, CST7, CYP4F3, LGALS12, MGAM, RGL4 +6 more | View in SCUBA |
| Natural Killer cells | Mature NK Identity Differentiation | ABCB1, ADAM28, CCDC141, CD160, CMTM7, DZIP3, IKZF3, LZTFL1 +5 more | View in SCUBA |
| Neutrophils | C5aR Complement Activation Innate immunity | C5AR1, CD55, ITPRIP, LAPTM5, MCL1, PFKFB3, PTPRE, RYBP +3 more |
About the gene
| Synonyms | GPR97, Pb99, PGR26 |
|---|---|
| Chromosome | 16: 57668277-57689378 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Plasma proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11- deoxycortisol. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity. May also signal through G-alpha(q)- proteins; additional evidence are however required to confirm this result in vivo. Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity. Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes. Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.