CCDC141 — Coiled-coil domain containing 141
CCDC141 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCDC141's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | IL10/cytokine signaling Immune regulation | CASK, FOXN3, IL10RA, IL7, SLC12A6, STAMBPL1, TMEM154, TNFRSF13B +4 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AKAP5, AOAH, CD8A, CD8B, CDYL, CRTAM, CYSTM1, DGKH +20 more | |
| Hematopoietic progenitor cells | ILC/NK Development Lymphcyte development | ACY3, ADGRD1, ATP10A, CD3E, CYSLTR1, ID2, ITGB7, NFATC4 +7 more | |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | EFNB2, EPB41, FBXO34, FGD6, GUCY1A1, ITGA6, MDFIC, NAV1 +13 more | View in SCUBA |
| Natural Killer cells | Mature NK Identity Differentiation | ABCB1, ADAM28, ADGRG3, CD160, CMTM7, DZIP3, IKZF3, LZTFL1 +5 more | View in SCUBA |
About the gene
| Synonyms | CAMDI, FLJ39502 |
|---|---|
| Chromosome | 2: 178829757-179050137 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Plays a critical role in cortical radial and GnRH neurons migration during brain development. Regulates cortical radial migration by negatively controlling the activity of histone deacetylase 6 (HDAC6) and promotes centrosome maturation. CAMDI is required for dilation formation of cortical neurons during radial migration. Plays a critical role in learning and memory performance through regulation of AMPA- selective glutamate receptors (AMPARs) cell surface expression in competition with KIBRA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.