ADAM28 — ADAM metallopeptidase domain 28

ADAM28 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ADAM28's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Adhesion/Migration migration & adhesion	ADAMTS6, ARHGAP24, ARHGAP5, CHPT1, CLMN, CMTR2, FCMR, JAM3 +11 more	View in SCUBA
Fibroblasts	Homeostatic Fibroblast State Housekeeping	APOE, CCL13, CCL8, COLEC11, CRYBG3, ELANE, FABP4, FABP5 +5 more	View in SCUBA
Gamma-delta T cells	Gut-homing Residence Tissue residence	ASB2, ATP8B4, CAPG, CCR9, CD101, CD9, DAPK2, DENND1B +8 more
Hematopoietic progenitor cells	Lymphoid Progenitor TFs Lymphcyte development	AFF3, ANKRD44, CYFIP2, CYLD, HLA-DMB, MEF2C, PDE7A, RNASEH2B +4 more
Macrophages	DNA Damage Repair Stress	ABCC5, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CHD9, CREBRF +27 more	View in SCUBA
Natural Killer cells	Mature NK Identity Differentiation	ABCB1, ADGRG3, CCDC141, CD160, CMTM7, DZIP3, IKZF3, LZTFL1 +5 more	View in SCUBA
Smooth muscle cells	Microfibril ECM Assembly ECM remodeling	FBN2, ITGA9, NEO1, NID1, PROM1, PSD3, SERPINE2, SPON1 +2 more	View in SCUBA

About the gene

Synonyms	ADAM23, eMDCII, MDC-Lm, MDC-Ls
Chromosome	8: 24294069-24359014
Predicted location	Membrane, Secreted
Essential gene	No
Protein class	Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Molecular function	Hydrolase, Metalloprotease, Protease

Function

May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.