Mature NK Identity
Gene co-expression module in Natural Killer cells
| Category | Differentiation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes CD160 (NK activating receptor), ABCB1 (P-glycoprotein marking mature/adaptive NK cells), IKZF3 (Aiolos, mature lymphocyte TF), CMTM7 (NK/B cell surface molecule), ADGRG3 (adhesion GPCR on NK cells), PIK3CD (PI3K-delta, lymphocyte signaling), and PRKCA (PKC-alpha, NK activation signaling) collectively define a mature NK cell identity program. ABCB1 in particular marks adaptive/mature NK cells. Upregulation in CD inflammation is consistent with mature NK cell expansion. Neighbor M72 also contains NK receptor genes, supporting this NK identity interpretation.
Genes
ABCB1, ADAM28, ADGRG3, CCDC141, CD160, CMTM7, DZIP3, IKZF3, LZTFL1, PIK3CD, PRKCA, SURF4, TTN, UGP2
Most correlated modules
- NK Inflammatory Activation · correlation 0.82
- Hypoxia Response · correlation 0.82
- Resident NK program · correlation 0.81
- NK Cytoskeletal Activation · correlation 0.78
- NK Tissue Residency · correlation 0.78
- NK Checkpoint Receptors · correlation 0.78
- ILC1/NK Cytotoxic · correlation 0.71
- Tissue-Resident NK · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.