AEN — Apoptosis enhancing nuclease
AEN belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AEN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | p53 DNA-damage response Stress | APOBEC3H, BBC3, DDB2, FDXR, GZMH, PHLDA3, PKIG, RCAN2 | View in SCUBA |
About the gene
| Synonyms | FLJ12484, FLJ12562, ISG20L1 |
|---|---|
| Chromosome | 15: 88621337-88632281 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Exonuclease, Hydrolase, Nuclease |
| Biological process | Apoptosis, DNA damage |
Function
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single- stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.