GZMH — Granzyme H
GZMH belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GZMH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | p53 DNA-damage response Stress | AEN, APOBEC3H, BBC3, DDB2, FDXR, PHLDA3, PKIG, RCAN2 | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Effector cytotoxicity | APOBEC3H, B2M, CCL4, CCL5, CD52, CYBA, HCST, HLA-A +4 more | View in SCUBA |
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | ADGRG1, ANXA4, CADM1, CX3CR1, FCGR3A, FGFBP2, FGL2, GNLY +14 more | |
| Natural Killer cells | NK Activation Signaling activation | C12orf75, F2R, GRAP2, LIME1, LYAR, RGS9, SSBP3, SYT11 +1 more | View in SCUBA |
About the gene
| Synonyms | CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2 |
|---|---|
| Chromosome | 14: 24606480-24609699 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Cytolysis |
Function
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.