PKIG — CAMP-dependent protein kinase inhibitor gamma
PKIG belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PKIG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Membrane adhesion remodeling migration & adhesion | ARL6IP5, ATP6V0E1, CAMK1D, CAST, CELF2, DDAH2, EMP3, FLNA +6 more | View in SCUBA |
| CD4⁺ T cells | p53 DNA-damage response Stress | AEN, APOBEC3H, BBC3, DDB2, FDXR, GZMH, PHLDA3, RCAN2 | View in SCUBA |
| Endothelial | Vascular Tone Regulation Endothelial cell development | ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CALD1, CAVIN3, CCDC3, CD81 +13 more | View in SCUBA |
| Fibroblasts | Metabolic Homeostasis Housekeeping | ADH5, ALDH2, ATP2B1, ISCU, NBL1, NLGN4X, PGM1, RAB7A +4 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Differentiation Erythropoietic | DHRS11, DNAJC6, EPOR, FHL2, GATA1, HBD, KLF1, LXN +5 more | |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | ANTXR1, BAG2, CDH11, COL12A1, CTSB, FHL3, FSTL3, HEPH +6 more | View in SCUBA |
About the gene
| Chromosome | 20: 44531785-44624247 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Protein kinase inhibitor |
Function
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.