AGO3 — Argonaute RISC catalytic component 3
AGO3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGO3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Epigenetic Remodeling Housekeeping | AFF4, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1, JMJD1C +16 more | View in SCUBA |
About the gene
| Synonyms | EIF2C3, FLJ12765, hAGO3 |
|---|---|
| Chromosome | 1: 35930718-36072500 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Endonuclease, Hydrolase, Nuclease, Ribonucleoprotein, RNA-binding |
| Biological process | RNA-mediated gene silencing, Translation regulation |
Function
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.