EPC1 — Enhancer of polycomb homolog 1
EPC1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EPC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Modification DNA/chromatin regulation | AKAP13, CREBRF, GCC2, GPBP1, JMJD1C, KMT2E, OFD1, PPP1R2 +6 more | View in SCUBA |
| CD4⁺ T cells | Transcription/RNA processing RNA processing | ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1 +29 more | View in SCUBA |
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | BCLAF1, CENPC, CLK1, CNOT1, COG3, COPS2, DDX24, DDX3X +11 more | |
| Innate lymphoid cells | NK/ILC1 Identity Differentiation | ABCA5, ARHGAP15, CD37, CD96, CD99, CTSD, GIMAP2, GIMAP6 +17 more | View in SCUBA |
| Macrophages | Epigenetic Remodeling Housekeeping | AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, JMJD1C +16 more | View in SCUBA |
| Natural Killer cells | Glucocorticoid Response Immune regulation | AREG, ARF6, BCLAF1, BEX2, BEX4, ELF1, ELL2, GABARAPL1 +11 more | View in SCUBA |
| Smooth muscle cells | Translation initiation/RNA-binding RNA processing & translation | BRI3, CDV3, EIF5, FAM133B, FAM53C, FUS, MAFB, PPP1R10 +2 more | View in SCUBA |
About the gene
| Synonyms | Epl1 |
|---|---|
| Chromosome | 10: 32267751-32378798 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, Chromatin regulator |
| Biological process | Differentiation, Growth regulation, Spermatogenesis, Transcription, Transcription regulation |
Function
Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.