ELF1 — E74 like ETS transcription factor 1

ELF1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ELF1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B Cell Identity Signaling B cell maturation	ARID4B, LYN, PAX5, RHOH, ST8SIA4, TMEM131, UGCG	View in SCUBA
CD4⁺ T cells	Transcription/RNA processing RNA processing	ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1 +29 more	View in SCUBA
Gamma-delta T cells	mRNA Splicing Regulation RNA processing & translation	ARF6, BTG3, CAPN7, CDV3, CELF2, CNBD2, CUL3, CYTIP +18 more
Innate lymphoid cells	Lymphocyte Apoptosis Regulation Immune regulation	ANP32B, ARMCX3, CCDC69, CHD2, DHRS7, FXYD5, GLIPR1, LEPROTL1 +14 more	View in SCUBA
Macrophages	Epigenetic Remodeling Housekeeping	AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, EPC1, JMJD1C +16 more	View in SCUBA
Mucosal-associated invariant T cell	Hypoxia-ER Stress Stress	ANKHD1, ARID1A, ARID4B, ATXN7, CEMIP2, CPD, CTDP1, EIF2AK3 +5 more
Natural Killer cells	Glucocorticoid Response Immune regulation	AREG, ARF6, BCLAF1, BEX2, BEX4, ELL2, EPC1, GABARAPL1 +11 more	View in SCUBA

About the gene

Chromosome	13: 40931924-41061440
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.