AFF4 — ALF transcription elongation factor 4
AFF4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AFF4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA Splicing RNA processing | ARL6IP1, CALR, CCNL1, CLK1, DDX3X, DDX5, EIF4A2, HSPA5 +7 more | View in SCUBA |
| CD4⁺ T cells | Epigenetic regulation DNA/chromatin regulation | ARID1B, CTSA, DGKH, FUBP1, JARID2, PDCD6, SYNCRIP, TET2 +6 more | View in SCUBA |
| Fibroblasts | Unfolded Protein Response Stress | ADM, DDX3X, DLL1, EIF4A1, ERN1, HNRNPA2B1, HNRNPH1, HNRNPU +5 more | View in SCUBA |
| Gamma-delta T cells | TCR Inhibitory Signaling Exhaustion | CBLB, CCNH, CCNT1, CHD2, CRYBG1, FYN, ISG20, PARP8 +9 more | |
| Macrophages | Epigenetic Remodeling Housekeeping | AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1, JMJD1C +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Signal Attenuation Immune regulation | BORCS5, CENPC, CHD2, CRACR2A, CRYBG1, DUSP16, FAS, FNBP1 +8 more |
About the gene
| Synonyms | AF5Q31, MCEF |
|---|---|
| Chromosome | 5: 132875395-132963634 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.