Epigenetic Remodeling
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 25 genes have a known function matching the annotation |
Why this annotation
The module is dominated by chromatin-modifying enzymes: KMT2C and KMT2E (H3K4 methyltransferases), ASH1L (H3K36 methyltransferase), SETD5 (H3K36 methyltransferase), JMJD1C (H3K9 demethylase), KDM2A (H3K36/H3K4 demethylase), KAT6A (H3K9/K14 acetyltransferase), EPC1 (NuA4/Polycomb-associated), EHMT1-neighbor context. TET2 is a canonical myeloid DNA demethylase critical for macrophage epigenetic programming. AFF4 (super elongation complex), AGO3 (RNA silencing/Argonaute), RC3H1 (Roquin mRNA stability regulator), and RBM47/RBM33 (RNA binding) add post-transcriptional regulation. This is the clearest module in the batch: a chromatin and epigenetic remodeling program highly characteristic of monocyte-derived macrophages, where TET2 and KMT2 family members are well-established regulators of myeloid identity and inflammatory gene expression.
Genes
AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1, JMJD1C, KAT6A, KDM2A, KMT2C, KMT2E, LUC7L, MARK3, PCNX1, PRDM2, RBM33, RBM47, RC3H1, RNF19A, SETD5, TET2, TRA2A, ZNF644
Most correlated modules
- Ubiquitin-Proteasome Regulation · correlation 0.99
- Endosomal Vesicle Trafficking · correlation 0.97
- Rho GTPase Signaling · correlation 0.96
- Chromatin Epigenetic Regulation · correlation 0.96
- Transcriptional Repression · correlation 0.96
- Post-transcriptional Regulation · correlation 0.96
- Transcriptional Regulation · correlation 0.95
- Chromatin Regulatory Genes · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.