ARID4B — AT-rich interaction domain 4B
ARID4B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARID4B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B Cell Identity Signaling B cell maturation | ELF1, LYN, PAX5, RHOH, ST8SIA4, TMEM131, UGCG | View in SCUBA |
| CD4⁺ T cells | MAF regulatory program Immune regulation | AKAP13, DTHD1, FYN, IKZF3, ISCU, LIMA1, LIMS1, MAF +12 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ADNP2, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C, JMY +17 more | |
| Innate lymphoid cells | ILC Survival Residency Gut residency | BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4, ENTPD1 +25 more | View in SCUBA |
| Macrophages | Epigenetic Remodeling Housekeeping | AFF4, AGO3, AKAP13, ASH1L, CYTH1, ELF1, EPC1, JMJD1C +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Hypoxia-ER Stress Stress | ANKHD1, ARID1A, ATXN7, CEMIP2, CPD, CTDP1, EIF2AK3, ELF1 +5 more | |
| Neutrophils | Ubiquitin Regulatory Signaling Housekeeping | CYRIB, FBXW7, GRB2, QKI, RAB1A, SIK3, STK10, USP9X |
About the gene
| Synonyms | BCAA, BRCAA1, RBP1L1, SAP180 |
|---|---|
| Chromosome | 1: 235131634-235328219 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.