AMPD2 — Adenosine monophosphate deaminase 2
AMPD2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AMPD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Anti-inflammatory Response Inflammatory | ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3, EIF4B +31 more | View in SCUBA |
| Monocytes | Non-canonical NF-κB Innate immunity | BCL3, BEST1, DENND5A, FAM20A, NFKB2, NOCT, RELB, TICAM1 | View in SCUBA |
About the gene
| Synonyms | SPG63 |
|---|---|
| Chromosome | 1: 109616104-109632051 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Nucleotide metabolism |
Function
AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.