EIF4B — Eukaryotic translation initiation factor 4B

EIF4B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EIF4B's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Leukocyte adhesion signaling migration & adhesion	ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, GYPC +22 more	View in SCUBA
Endothelial	Translation Elongation RNA processing & translation	CCNI, COMMD6, EEF1A1, EEF1B2, EEF2, EIF3F, EIF3L, FBL +7 more	View in SCUBA
Gamma-delta T cells	Translation & Proteostasis RNA processing & translation	ARAP2, ATG13, BRPF1, CLINT1, CRKL, E2F3, EEF2, EIF2AK2 +15 more
Innate lymphoid cells	Interferon-Stimulated Genes Inflammation	ALDOA, CRTAP, DAZAP2, DDX39B, GDI1, GNB2, GRINA, GSTM2 +17 more	View in SCUBA
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more	View in SCUBA
Monocytes	Tissue-Resident Macrophage Tissue adaptation	ALDH1A1, CPED1, DAAM2, FN1, H2AC19, HDAC9, IGHA2, LPL +3 more	View in SCUBA
Mucosal-associated invariant T cell	Co-transcriptional Splicing RNA processing & translation	C9orf78, CCDC85C, CCNK, CDKN1B, DNTTIP2, ILF3, LAPTM5, MADD +16 more

About the gene

Chromosome	12: 53006282-53042215
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Molecular function	Initiation factor, RNA-binding
Biological process	Protein biosynthesis

Function

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.