Anti-inflammatory Response
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 40 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 40 genes have a known function matching the annotation |
Why this annotation
TSC22D3 (GILZ) is a canonical glucocorticoid-induced anti-inflammatory transcription factor. IL10RA mediates IL-10 anti-inflammatory signaling. RGS2 and RGS1 dampen G-protein/chemokine receptor signaling. KLF2 suppresses inflammatory gene expression. PTGER4 (EP4 prostaglandin receptor) promotes immunomodulation. CEBPD and TRIB1 regulate myeloid differentiation and anti-inflammatory states. SESN2 and HERPUD1 reflect stress-adaptive responses. ZFP36L2 destabilizes pro-inflammatory mRNAs. Together these genes form an anti-inflammatory/immunomodulatory program, contrasting with the NF-κB activation in neighboring M93 and M150.
Genes
AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3, EIF4B, FOXP1, GZF1, HERPUD1, ID2, IER5, IL10RA, KLF2, LILRB1, MS4A7, OTUD1, PABPC1, PABPC4, PER1, POLR3E, PTGER4, RGS1, RGS2, RHOB, SERPINB9, SESN2, SP140L, TAGAP, TAMALIN, TOB1, TRIB1, TSC22D3, TSPYL1, TUG1, VCPIP1, VEGFA, ZFP36L2
Most correlated modules
- Splicing Factor Regulation · correlation 0.94
- Early response genes · correlation 0.94
- Macrophage Lipid Sensing · correlation 0.92
- Mixed Regulatory Signaling · correlation 0.91
- NF-κB Activation · correlation 0.91
- Endosomal Membrane Trafficking · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.