BST1 — Bone marrow stromal cell antigen 1
BST1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BST1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, FN1, GCHFR +19 more | View in SCUBA |
About the gene
| Synonyms | BST-1, cADPR2, CD157 |
|---|---|
| Chromosome | 4: 15703065-15738313 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | CD markers, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Transferase |
Function
Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.