SPP1 Tissue Remodeling
Gene co-expression module in Macrophages
| Category | ECM remodeling |
|---|---|
| Genes | 28 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 20 genes have a known function matching the annotation |
Why this annotation
SPP1 (osteopontin, tissue remodeling/fibrotic macrophage marker), FN1 (fibronectin, ECM), CHI3L1 (chitinase-like protein, tissue remodeling/M2 macrophage), LPL (lipoprotein lipase, lipid metabolism in tissue macrophages), CSF1 (macrophage colony-stimulating factor, autocrine macrophage survival/differentiation), FBP1 (gluconeogenesis), SEMA3C (semaphorin, guidance/remodeling), FGR (Src-family kinase, myeloid signaling), MATK (tyrosine kinase), KCNN4 (calcium-activated K channel, macrophage activation), LILRA6 (inhibitory Ly49-like receptor), GLIPR2 (immune regulation). The SPP1+FN1+CHI3L1+LPL combination is characteristic of tissue-remodeling/SPP1-high macrophages described in gut inflammation and fibrosis. Strong mono_mac enrichment.
Genes
BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, FN1, GCHFR, GLIPR2, HK3, HSD3B7, KCNN4, LILRA6, LPL, MARCO, MATK, MYOF, NIBAN1, QPCT, RAC2, RETN, RMDN3, SCCPDH, SEMA3C, SNTB1, SPN, SPP1
Most correlated modules
- Inflammatory Monocyte Activation · correlation 0.92
- Myeloid Immune Checkpoint · correlation 0.87
- Hypoxia Stress Response · correlation 0.86
- Inflammatory Monocyte Activation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.