FN1 — Fibronectin 1
FN1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | YAP Mechanotransduction migration & adhesion | COBLL1, CREB5, DEPP1, DST, FGL2, FLNC, GCNT2, GLIPR2 +7 more | View in SCUBA |
| Fibroblasts | Elastin-Fibronectin ECM ECM production | ABI3BP, DDAH2, ELN, LRIG3, S100A4, SERPINE2, SOD3, SSC5D | View in SCUBA |
| Glial cells | Reactive Glial Activation Activation | AEBP1, ATP5F1E, EEA1, F2R, IFI16, POLR2L, PRSS23, PSMA4 | View in SCUBA |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, GCHFR +19 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Tissue adaptation | ALDH1A1, CPED1, DAAM2, EIF4B, H2AC19, HDAC9, IGHA2, LPL +3 more | View in SCUBA |
| Pericytes | Inflammatory ECM Remodeling ECM remodeling | CCDC80, CD44, FHL2, FMO3, PDLIM3, RARRES2, TGFBI, TNC +1 more | View in SCUBA |
| Smooth muscle cells | Collagen Biosynthesis ECM remodeling | CALU, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL6A1, COL6A2 +4 more | View in SCUBA |
About the gene
| Synonyms | CIG, FINC, GFND2, LETS, MSF |
|---|---|
| Chromosome | 2: 215360440-215436073 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Heparin-binding |
| Biological process | Acute phase, Angiogenesis, Cell adhesion, Cell shape |
Function
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation. Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.