General Cellular Maintenance
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 20 of 22 genes have a known function matching the annotation |
Why this annotation
All hub genes show weak membership and uniform expression with unknown coherence, indicating a poorly co-regulated module. The genes span diverse housekeeping functions: RNA binding/splicing (HNRNPUL1, SNRNP200, PURA, RBM12, FMR1, THUMPD1), signaling (PDPK1, AKT2, SHC1), ubiquitin/cell cycle (FBXL3, DCUN1D1, TACC1), vesicular trafficking (VPS36, GCC2, GAK), and lipid transcription (SREBF1). No single tight biological program dominates. The uniform expression across subsets and all-weak membership scores indicate this is a loosely co-expressed general cellular maintenance module, likely reflecting background co-variation of broadly expressed housekeeping genes.
Genes
ABHD13, AKT2, AMD1, C1GALT1, DCUN1D1, FBXL3, FMR1, GAK, GCC2, HNRNPUL1, PDPK1, PTCD3, PURA, RBM12, SHC1, SNRNP200, SREBF1, SWAP70, TACC1, THUMPD1, TMEM259, VPS36
Most correlated modules
- RNA Splicing Processing · correlation 0.98
- Ubiquitin-ERAD Proteostasis · correlation 0.97
- Chromatin Transcriptional Regulation · correlation 0.97
- mRNA Splicing Processing · correlation 0.96
- Pre-mRNA Splicing · correlation 0.96
- RNA Processing Regulation · correlation 0.96
- ER-Golgi Trafficking · correlation 0.96
- TGF-beta Signaling · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.