EPCAM — Epithelial cell adhesion molecule
EPCAM belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EPCAM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | High-abundance housekeeping Housekeeping | ARPC3, CD63, CYSTM1, DYNLL1, EIF1, H3-3A, H3-3B, S100A10 +1 more | View in SCUBA |
| Goblet cells | Epithelial Membrane Identity Epithelial development | EIF3H, ITM2B, PDLIM1, RAC1, SLC25A3, TMEM176A, TMEM176B, TMEM59 +1 more | View in SCUBA |
About the gene
| Synonyms | 17-1A, 323/A3, Ber-Ep4, BerEp4, CD326, CO-17A, EGP-2, EGP34, EGP40, Ep-CAM, ESA, GA733-2, HEA125, KS1/4, KSA, Ly74, M4S1, MH99, MIC18, MK-1, MOC-31, MOC31, TACST-1, TACSTD1, TROP1 |
|---|---|
| Chromosome | 2: 47345158-47387601 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Tumor antigen |
Function
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.