CCN2 — Cellular communication network factor 2
CCN2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | CCN1, DUSP2, FOXC1, GADD45B, GADD45G, GATA2, HES5, HSPA2 +9 more | View in SCUBA |
About the gene
| Synonyms | CTGF, IGFBP8 |
|---|---|
| Chromosome | 6: 131948176-131951372 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Heparin-binding |
| Biological process | Cell adhesion, DNA synthesis |
Function
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor- induced DNA synthesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.