SCUBA

DUSP2 — Dual specificity phosphatase 2

DUSP2 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DUSP2's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsImmediate Early NFkB
BCR/AP1/NFKb pathway
ARL5B, CDKN1A, CSRNP1, EGR1, EGR3, IER2, NFKBIA, PPP1R15B +3 moreView in SCUBA
CD4⁺ T cellsNF-kB activation
TCR/AP1/NFKb pathway
ADRA2B, CD83, CHD4, CYB5D1, EGR2, EGR3, EGR4, FOSL1 +9 moreView in SCUBA
CD8⁺ T cellsEffector-Memory CD8
T cell maturation
CD27, CD44, CMC1, CST7, CXCR3, EOMES, F2R, HLA-E +8 moreView in SCUBA
Gamma-delta T cellsHeat Stress Apoptotic
Stress
AMD1, DBF4, DNAJB9, IER5, NFKBIB, NINJ1, PHLDA1, PMAIP1 +5 more
Goblet cellsNF-kB Inflammatory Signaling
chromatin regulation & transcription
CD69, CXCR4, DDX21, FOSL2, IRF1, NFKB2, REL, RGCC +5 moreView in SCUBA
Innate lymphoid cellsNF-κB Inflammatory Activation
Inflammation
CDKN1A, CSRNP1, DUSP1, DUSP6, ELL2, EZR, FOS, ICAM1 +26 moreView in SCUBA
Lymphatic endothelialLymphatic Valve Formation
Valve formation
CCN1, CCN2, FOXC1, GADD45B, GADD45G, GATA2, HES5, HSPA2 +9 moreView in SCUBA
MacrophagesNF-κB Effector Response
Inflammatory
ARL5B, BIRC3, CYB5D1, EGR3, HES1, ICAM4, PTGS2, SIK1View in SCUBA
MonocytesImmediate-Early Inflammatory
Inflammatory
CXCL2, CXCL3, CXCL8, EGR1, EGR2, NFKBIA, NFKBIZ, OTUD1 +3 moreView in SCUBA
Mucosal-associated invariant T cellmRNA Decay Program
RNA processing & translation
ATP6V0C, BCL7B, BTG1, BTG3, CCDC59, DDIT4, DYNLL2, EXOSC6 +13 more
Natural Killer cellsAP-1 Immediate Early
activation
BTG1, CITED2, CXCR4, DUSP1, FOS, JUN, JUNB, KLF6 +1 moreView in SCUBA
NeutrophilsHeat Shock Response
Stress
ATP6V0C, CYB5D1, DNAJA1, GNG10, HMOX1, HSP90AA1, HSP90AB1, HSPA1A +4 more

About the gene

SynonymsPAC-1
Chromosome2: 96143169-96145440
Predicted locationIntracellular
Essential geneNo
Protein classEnzymes, Predicted intracellular proteins
Molecular functionHydrolase, Protein phosphatase

Function

Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine. Can dephosphorylate MAPK1 (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.