Lymphatic Valve Formation
Gene co-expression module in Lymphatic endothelial
| Category | Valve formation |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
Hub gene NRARP is a Notch/Wnt target and negative regulator of Notch signaling critical for lymphatic valve formation. GATA2 is a master transcription factor for lymphatic valve specification. FOXC1 is a FOXC family member essential for lymphatic valve development. ID1 and ID3 are BMP-responsive HLH factors involved in endothelial/lymphatic identity. HES5 is a canonical Notch target. CCN1 and CCN2 (CYR61/CTGF) are mechanosensitive matricellular proteins expressed in valve-forming LECs. KLF10 is a TGF-β/BMP-responsive Krüppel-like factor. GADD45B and GADD45G are stress/growth-arrest genes but also appear in valve-related contexts. SGK1 is a flow-responsive kinase in LECs. IER5/IER5L are immediate-early genes. The convergence of NRARP, GATA2, FOXC1, ID1/ID3, HES5, and CCN1/CCN2 strongly indicates a lymphatic valve formation / Notch-BMP signaling program, consistent with the intestinal lymphatic context.
Genes
CCN1, CCN2, DUSP2, FOXC1, GADD45B, GADD45G, GATA2, HES5, HSPA2, ID1, ID3, IER5, IER5L, KLF10, NRARP, RASD1, RGS16, SGK1
Most correlated modules
- Heat Shock Response · correlation 0.82
- Hypoxic Stress Response · correlation 0.80
- DNA Damage Response · correlation 0.78
- Integrated Stress Response · correlation 0.77
- AP-1 Immediate Early · correlation 0.77
- Notch TGF-β Endothelial · correlation 0.70
- Stress Granule Assembly · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.