HES5 — Hes family bHLH transcription factor 5
HES5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HES5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Endothelial cell development | CCRL2, CDC42EP3, CGAS, CHSY1, CYTH1, HIPK3, ID1, ID3 +7 more | View in SCUBA |
| Goblet cells | Notch Secretory Specification Epithelial development | EDN1, EREG, FKBP1A, GPRC5C, HES4, MYC, NOTCH2, PDGFA +4 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | CCN1, CCN2, DUSP2, FOXC1, GADD45B, GADD45G, GATA2, HSPA2 +9 more | View in SCUBA |
About the gene
| Synonyms | bHLHb38 |
|---|---|
| Chromosome | 1: 2528745-2530263 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding, Repressor |
| Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Function
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.