DDX27 — DEAD-box helicase 27
DDX27 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDX27's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCM2, CCR4, CD28, CREBRF, ERBIN, ICOS +10 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing RNA processing & translation | ARHGDIA, DDX59, EIF2AK1, EWSR1, FBXL5, GNL1, GTF2F1, HNRNPM +14 more | |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DNMT1 +29 more | View in SCUBA |
| Macrophages | Macrophage Lipid Sensing Lipid metabolism | ARL4A, ARL4C, BIRC2, CES2, DDX21, DDX24, GPR183, IDI1 +12 more | View in SCUBA |
About the gene
| Synonyms | dJ686N3.1, DRS1 |
|---|---|
| Chromosome | 20: 49219347-49244077 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA
Human Protein Atlas · Open Targets
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.