DDX24 — DEAD-box helicase 24
DDX24 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDX24's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chemokine Migration migration & adhesion | CCR6, CYTIP, FRMD4B, G3BP2, GNG2, GPBP1, KMT2E, PDE4B +7 more | View in SCUBA |
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | BCLAF1, CENPC, CLK1, CNOT1, COG3, COPS2, DDX3X, EPC1 +11 more | |
| Innate lymphoid cells | NR4A Activation Response activation | ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DLL1, DNAJB9 +16 more | View in SCUBA |
| Macrophages | Macrophage Lipid Sensing Lipid metabolism | ARL4A, ARL4C, BIRC2, CES2, DDX21, DDX27, GPR183, IDI1 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | Splicing Regulation RNA processing & translation | AREG, ARHGAP9, AZIN1, CCNH, CLK1, DNAJB6, IL23R, NEU1 +9 more | |
| Natural Killer cells | NK Cell Activation activation | AKAP9, AKIRIN1, ALG13, EIF1AX, ETF1, EZR, GNL3, PPP1CB +2 more | View in SCUBA |
| Smooth muscle cells | Calcium Handling Contractility | ASAP2, MYCBP2, NBDY, PDE1A, RBM24, RNF180, RRAS, RYR2 +3 more | View in SCUBA |
About the gene
| Chromosome | 14: 94048287-94081202 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, RNA-binding |
| Biological process | Host-virus interaction |
Function
ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.